Antone’s Famous Po’ Boys Houston Medical Center Restaurant Is Now Open

The storefront of the new Antone's Famous Po' Boys at the Medical Center in Houston

Approximately nine months in the making, Antone’s Famous Po’ Boys’ new location at 6618 Fannin in the Medical Center area is now open. It’s the first full-fledged new one since the West Loop location debuted over a decade ago. (In the interim, Antone’s Famous Po’ Boys opened a kiosk at Greenway Plaza, and rapidly grew the business by expanding its deliveries to Austin in 2018.)

Specifically, the new shop is on the first floor of the Medical Towers Building at the corner of Fannin and Dryden. Local firm Gin Design Group — known for its work on Eunice and the Memorial-area Dish Society location, among others  — applied special interior touches (and are soon upgrading the existing restaurants on T.C. Jester and West Loop South) while Houston builder Construction Concepts handled the overall buildout. 

Muffuletta at Antone's Famous Po' Boys
Muffuletta at Antone’s Famous Po’ Boys. Photo by Rebecca Wright Photography.

The new location offers the same menu and pricing as the others. In addition to the namesake po’ boys, owner company Legacy Restaurant Group, which also operates The Original Ninfa’s, often taps executive chef Alex Padilla to create new dishes. Several of his original creations are on the menu, including the Tex-Mex Cheesesteak, which was named the 2019 Best Sandwich in America by the Restaurant Hospitality website. Many of the dishes are not only housemade but hot. These include an excellent pressed Cuban sandwich, gumbo (vegetarian, chicken & andouille and seafood), a great fried seafood platter and a muffuletta with ham, mortadella, salami, provolone, olive salad and the proper type of bread.

Antone Famous Po Boy stack
A selection of neatly wrapped sandwiches from Antone’s Famous Po’ Boys. Photo by Cooper + Ricca.

Customers short on time are likely to find the new Express Lane handy. It allows them to grab the traditional po’ boys (Original, Super Original, Piggy, Turkey & Swiss, Pimento Cheese or Tuna), salads, sides, dessert (such as the hefty brownie or cookies) or drinks from the cold cases, check out and be on their way. Businesses in the Medical Center are likely to benefit from the party trays and catering service available for pickup or delivery.

“We are very pleased with our expanded menu featuring a wide variety of sandwiches, gumbos, salads, and packaged ‘grab and go’ items – we think this is a perfect fit for the employees and visitors in the Medical Center – whether they’re looking for a quick bite on the run or a seated meal,” said Legacy Restaurants CEO Jonathan Horowitz via a press release. 

Antone’s Famous Po’ Boy hours are Monday through Friday from 10 a.m. to 7 p.m., Saturday from 10 a.m. to 5 p.m. and Sunday from 11 a.m. to 4 p.m. Its phone number is (832) 667-1873 and additional information is on the website

Comments (3)

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  • January 26, 2020 at 2:43 pmsidney delaney

    now that our Randalls grocery store in Kingwood will be closing I have no way to get my Original PoBoy..will you be supplying other grocery stores in the area?

  • January 11, 2020 at 2:46 pmArnita Matt

    Very disappointed in the customer service at the Antone’s in the medical center. For the amount of money me and my co-workers spent in this place we should be afforded better service. The man that waited on me was unprofessional and in a way rude. I say rude because I asked him a question about your gumbo that you have (what was in it) and as I was telling him that I didn’t want the gumbo he walked away from the counter and started spooning out gumbo for another customer so I am trying to get his attention (excuse me, excuse me sir, sir, sir HELLOOO) I know he had to of heard me because the other cashier looked up and looked at him still no response. So he ignores me and starts to talk to one of the other workers there. Then comes to me and said can I help you. My first thought is to walk out and go to Chipole which is a few steps away but I believe in giving people the benefit of the doubt. So waiting on my order he calls a number so he is calling my order but he gave me the wrong call number. My co-worker’s order sat on the counter for a while before he announced what it was or called the number.
    I really don’t like spending my hard earned money at a place that makes me feel like I am not welcome. This team of workers need a class in customer relations.

    • January 13, 2020 at 10:27 amAntone's Famous Po' Boys

      Hey there, thank you for coming to see us and taking the time to share your honest feedback! Please know, this is absolutely not the experience we strive to give our customers. Customer service is our top priority and we sincerely apologize for the lack of service you received. Would you mind sending us a message with your contact information so we can reach out to you directly? We value your feedback and hope to have the chance to make things right with you! ([email protected])